TGN1412: Superagonist Dr. Jekyll and Superantigen Mr. Hyde
نویسنده
چکیده
Los anticuerpos anti-CD28 superagonistas inducen activación de los linfocitos T en ausencia de estimulación del TCR. Los ensayos clínicos de uno de tales anticuerpos, TGN1412, han resultado en severas complicaciones en los voluntarios que lo recibieron. El análisis de las características y modo de acción de los superagonistas de CD28 sugiere que dichos efectos son similares a los previamente observados con el uso terapeútico de anticuerpos anti-CD3 y al síndrome tóxico inducido por superantígenos bacterianos.
منابع مشابه
Dr. Jekyll or Mr. Hyde: Information Security in the Ecosystem of Healthcare
“Jekyll and Hyde” embodies how information security affects today’s healthcare ecosystem. When security works, it promotes patient health and a smooth operating ecosystem (Dr. Jekyll); when it doesn’t, privacy and health compromises can occur (Mr. Hyde). In this paper, we argue that unusable security triggers this split personality and in doing so, compromises the heart of the healthcare ecosys...
متن کاملLublin Studies in Modern Languages and Literature
The paper engages with Stevenson’s novel The Strange Case of Dr Jekyll and Mr Hyde from the perspective of essential duality embedded in every one’s nature: it explicates the entangling nature of binaries and the aesthetics of non-disjunction of the binary self/Other as embodied in the figures of Dr Jekyll and Mr Hyde respectively. By the novel’s end, the two aspects, the Jekyllean and the Hyde...
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